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Anna Akhmanova and Marileen Dogterom aim to understand the basic principles of internal cell organization. This knowledge will eventually make it possible to control essential cellular processes such as cell movement and division. “If you want to manipulate cells, for example to grow organs or to treat cancer, you have to understand how they function”, … Read more
The research group of Hoogenraad has recently developed new imaging tools to visualize and manipulate the cytoskeleton and transport components in living neurons. With the ERC grant they will focus on the changes that occur within the microtubule cytoskeleton during the different stages of neuronal polarization and differentiation. The ultimate goal is to understand how … Read more
Benoit RM, Frey D, Hilbert M, Kevenaar JT, Wieser MM, Stirnimann CU, McMillan D, Ceska T, Lebon F, Jaussi R, Steinmetz MO, Schertler GFX, Hoogenraad CC, Capitani G and Kammerer RA, Structural basis for recognition of synaptic vesicle protein 2C by botulinum neurotoxin A, Nature, 2013 Botulinum neurotoxin A (BoNT/A) belongs to the most dangerous … Read more
van der Vaart B, van Riel WE, Doodhi H, Kevenaar JT, Katrukha EA, Gumy L, Bouchet BP, Grigoriev I, Spangler SA, Yu KL, Wulf PS, Wu J, Lansbergen G, van Battum EY, Pasterkamp RJ, Mimori-Kiyosue Y, Demmers J, Olieric N, Maly IV, Hoogenraad CC, Akhmanova A. CFEOM1-Associated Kinesin KIF21A Is a Cortical Microtubule Growth Inhibitor. … Read more
Lukas Kapitein received a prestigious Starting Grant from the European Research Council. This 1.5 M€ grant is intended for excellent researchers with innovative proposals. The grant will allow Lukas Kapitein to expand the research of his lab on polarized transport in neurons. He will use super-resolution microscopy to dissect the organization of the neuronal microtubule … Read more
Marijn Kuijpers, Ka Lou Yu, Eva Teuling, Anna Akhmanova, Dick Jaarsma and Casper C. Hoogenraad. The ALS8 protein VAPB interacts with the ER–Golgi recycling protein YIF1A and regulates membrane delivery into dendrite. The EMBO Journal advance online publication 04 June 2013; doi:10.1038/emboj.2013.131 The vesicle-associated membrane protein (VAMP) associated protein B (VAPB) is an integral membrane … Read more
Samantha A. Spangler, Sabine K. Schmitz, Josta T. Kevenaar, Esther de Graaff, Heidi de Wit, Jeroen Demmers, Ruud F. Toonen and Casper C. Hoogenraad. Liprin-α2 promotes the presynaptic recruitment and turnover of RIM1/CASK to facilitate synaptic transmission. The Journal of Cell Biology, Vol. 201, No. 6, 10 June 2013. Nerve cells communicate via specialized contact … Read more
Mohan R, Katrukha EA, Doodhi H, Smal I, Meijering E, Kapitein LC, Steinmetz MO, Akhmanova A. End-binding proteins sensitize microtubules to the action of microtubule-targeting agents. Proc Natl Acad Sci U S A. 2013 May 28;110(22):8900-5. doi: 10.1073/pnas.1300395110. Epub 2013 May 14. Microtubule-targeting agents (MTAs) are widely used for treatment of cancer and other diseases, … Read more
